The TOID Center for Clinical Research
The comprehensive Transplant and Oncology Infectious Diseases (TOID) program was launched in 2008. The mission of the TOID Program, directed by Kieren Marr, MD, is to expand institutional expertise in clinical and academic activities focused on infectious complications in transplant (solid organ and stem cell) and oncology patients at Johns Hopkins Medical Institutions.
Key research efforts are currently directed to developing standardized algorithms for prevention and treatment of infections in these vulnerable patients and to establish an expanded infrastructure to facilitate clinical and translational studies in TOID.
Clinical research is supported by a team of clinical research nurses, database, and research specialists, with administrative and functional oversight provided by Darin Ostrander PhD and Christine Durand, MD
Faculty and Research Staff
Kieren Marr, MD
Kieren Marr, MD, Professor of Medicine and Oncology, is the Director of Transplant and Oncology Infectious Diseases and Vice Chair for Innovation in Healthcare Implementation, Johns Hopkins University. Dr. Marr investigates infectious complications in transplant (solid organ and stem cell) and oncology patients. Key research efforts are currently directed to developing standardized algorithms for prevention and treatment of infections in these vulnerable patients and to establish an expanded infrastructure to facilitate clinical and translational studies in TOID.
She is an elected member of the American Society for clinical Investigators (ASCI) and is known internationally for her translational and clinical research focused on diagnostics and treatment of invasive fungal infections. Her research has led to establishment of a JHU start-up company, MycoMed Technologies, focused on device and drug development in medically immunosuppressed people. Her interests in medical innovation and commercialization led to her appointment in the Johns Hopkins University Carey Business School.
Dr. Marr has authored over 150 peer-reviewed publications and textbook chapters, and edited two books in the area of infectious diseases involving immunosuppressed hosts. Marr Research Dashboard and Publications
Robin Kimiko Avery, MD
Robin Kimiko Avery, MD, Professor of Medicine, is an infectious disease physician who joined the Johns Hopkins faculty in 2012, with two decades of experience in transplant infectious disease. She is a past chair of the American Society of Transplantation (AST) Infectious Disease Community of Practice, was a co-editor of the first edition of the AST ID Guidelines, and has served on guidelines committees for the AST, the Infectious Disease Society of America (IDSA) and the International Society for Heart and Lung Transplantation (ISHLT), as well as the Centers for Disease Control and Prevention Zoster Vaccines Workgroup. She was the founding head of the Transplant Infectious Disease Section at the Cleveland Clinic and the founding director of the Cleveland Clinic Transplant ID Special Fellowship, authoring a curriculum that served as the basis for curricula later endorsed by the AST and IDSA. Her clinical and research interests include pre-transplant donor and recipient evaluation, and prevention and treatment of post-transplant infections, particularly transplant-associated viruses, viral load monitoring, novel therapies for CMV, hypogammaglobulinemia, immunizations, patient education, and strategies for safer living post-transplant. In 2017, Dr. Avery received the award for Best Consulting Physician at the Johns Hopkins Hospital. Avery Research Dashboard and Publications
Maria Veronica Dioverti-Prono, MD
Maria Veronica Dioverti-Prono, MDClinical Associate, received her MD from the Universidad Nacional de Asuncion and completed a residency at the Bridgeport Hospital of Yale University. She completed an Infectious Diseases fellowship and a Transplant/Oncology Infectious Diseases fellowship at the Mayo clinic in Rochester, MN. Dr. Dioverti-Prono provides clinical care to transplant, oncology, and other immunocompromised patients. Her research is focused on optimizing diagnosis of cytomegalovirus infection and fungal infections in hematologic malignancies. Dioverti-Prono Research Dashboard and Publications
Christine Durand, MD
Christine Durand, MD, Associate Professor of Medicine and Oncology, received her MD from Johns Hopkins University School of Medicine. This was followed by completion of a residency and Infectious diseases Fellowship at Johns Hopkins University School of Medicine.
Dr. Durand is a member of the Johns Hopkins Kimmel Cancer Center and is involved in clinical and translational research focused on individuals infected with HIV and hepatitis C virus who require cancer and transplant therapies. Her current research efforts include looking at outcomes of hepatitis C treatment after solid organ transplant, the potential use of organs from HIV-infected donors for HIV-infected solid organ transplant candidates, and HIV cure strategies including bone marrow transplantation.
Dr. Durand is supported by multiple grants: R01 from the National Institute of Allergy and Infectious Diseases (NIAID) to study HIV-to-HIV organ transplantation in the US; K23 from the National Cancer Institute (NCI) to study antiretroviral therapy during bone marrow transplant in HIV-1 infection; U01 from the NIAID to study HIV-to-HIV deceased donor kidney transplantation. Durand Research Dashboard and Publications
Nitipong (Nate) Permpalung, MD, MPH
Nitipong (Nate) Permpalung, MD, MPH, Clinical Associate, completed ID fellowship at Beth Israel Deaconess Medical Center/Harvard Medical School. He subsequently completed a year of Transplant ID fellowship at Duke University. There, he had a research focus in RSV infection in lung transplant recipients and fungal infections in the immunocompromised host.
Shmuel Shoham, MD
Shmuel Shoham, MD, Associate Professor of Medicine and Associate Director, Transplant and Oncology Infectious Diseases, has over 20 years of experience in management of patients with invasive infections, and is the author or co-author of over 100 original articles, book chapters and topic reviews. He is a nationally recognized expert in infectious diseases of immunocompromised patients and his research explores diagnosis, prevention and treatment of infections in such patients.
Dr. Shoham serves as a reviewer and expert consultant to multiple journals, professional societies, hospitals and government agencies in the US and numerous countries abroad. He is a member of professional guideline committees for the American Society of Transplantation (AST), the European Organization for Research and Treatment of Cancer/Invasive Fungal Infections Cooperative Group and Infectious Diseases Mycoses Study Group (EORTC/MSG) and the National Comprehensive Cancer Network (NCCN).
Dr. Shoham is the recipient of numerous awards including the American College of Physicians’ (Washington, DC Chapter) laureate award. their highest honor. Dr. Shoham received his medical degree from Thomas Jefferson University (Philadelphia, PA) and medical residency and infectious diseases fellowship training at Boston University School of Medicine (Boston, MA). Shoham Research Dashboard and Publications
Willa Cochran, CRNP
Willa Cochran is an Adult-Gerontological Nurse Practitioner with the Comprehensive Transplant Center. She received her BA at Skidmore College and earned her BSN and MSN at the Johns Hopkins School of Nursing through the Paul D. Coverdell Peace Corps Fellowship. While there, she earned her certificate of HIV Primary Care as a HRSA Advance Nursing Education Traineeship Scholar.
In June 2015 she joined the Johns Hopkins Hospital’s Comprehensive Transplant Center where her clinical and research practices focus on liver and/or kidney transplant recipients at increased risk for infectious complications. Ms. Cochran is committed to providing holistic, patient-centered care for transplant recipients living with HIV, Hepatitis C or at risk for Cytomegalorvirus and other infectious complications of transplant.
She and her colleagues have presented their work on CMV prevention at the Armstrong Institute Diagnostic Excellence Summit and the American Transplant Congress. She has also presented her work in clinical care for HIV positive transplant recipients who received organs from HIV positive deceased donors at the Association for Nurses in AIDS Care’s Chesapeake Chapter conference and was a featured speaker at the association’s national conference. She is the current President of the Association of Nurses in AIDS Care’s Chesapeake Chapter. Cochran Research Dashboard and Publications
Darin Ostrander, PhD
Darin Ostrander, PhD, Research Associate and Program Manager/Director of Operations, TOID, has more than 25 years’ experience in antimicrobial research and development. He assists investigators in administrative and regulatory aspects of clinical research, including IRB applications, NIH and pharmaceutical grant applications, budget development, multicenter administration, and database development. Ostrander Research Dashboard and Publications
Additional Research Staff
Diane Brown, RN, MSN
Senior HIV Research Nurse
Brittany Barnaba, RN, MS
Senior Research Nurse
Senior Research Program Coordinator II
JR Johnstone, MPH
Senior Research Program Coordinator
Obichukwu Ezennia, BS
Senior Research Program Coordinator
Na Lu, MA
Senior Research Assistant